930601

VH032-cyclopropane-F

≥95%

• Synonym(e): (S,R,S)-AHPC-cyclopropane-F, (2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (2S,4R)-1-[(S)-2-(1-Fluorocyclopropan-1-ylcarbonylamino)-3,3-dimethylbutanoyl]-4-hydroxy-N-[2-hydroxy-4-(4-methylthiazol-5-yl)benzyl]pyrrolidine-2-carboxamide, N-[(1-fluorocyclopropyl)carbonyl]-3-methyl-L-valyl-4-hydroxy-N-[[2-hydroxy-4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-, L-Prolinamide
• Empirische Formel (Hill-System): C₂₆H₃₃FN₄O₅S
• CAS-Nummer: 2306193-99-5
• Molekulargewicht: 532.63
• UNSPSC-Code: 12352101
• NACRES: NA.22

Eigenschaften

• ligand: VH032
• Qualitätsniveau: 100
• Assay: ≥95%
• Form: powder
• Eignung der Reaktion: reagent type: ligand
• Funktionelle Gruppe: hydroxyl
• Lagertemp.: 2-8°C
• SMILES String: C([C@@H](NC(=O)C1(F)CC1)[C@@](C)(C)C)(=O)N2[C@H](C(NCC3=C(O)C=C(C=C3)C4=C(C)N=CS4)=O)C[C@@H](O)C2

Beschreibung

Anwendung

VH032-cyclopropane-F is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal hydroxyl group. Allows rapid conjugation with many linkers containing active leaving groups. A basic building block for development of a protein degrader library.

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Sonstige Hinweise

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Impact of linker length on the activity of PROTACs

Rechtliche Hinweise

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable