930563

Pomalidomide-PEG₂-C₂-azide

≥95%

• Synonym(e): 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-Azidoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-[[2-[2-(2-Azidoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• Empirische Formel (Hill-System): C₁₉H₂₂N₆O₆
• CAS-Nummer: 2271036-45-2
• Molekulargewicht: 430.41
• MDL-Nummer: MFCD32903292
• UNSPSC-Code: 51471602
• NACRES: NA.21

Eigenschaften

• ligand: pomalidomide
• Qualitätsniveau: 100
• Assay: ≥95%
• Form: powder
• Funktionelle Gruppe: azide
• Lagertemp.: 2-8°C

Beschreibung

Anwendung

Pomalidomide-PEG₂-C₂-azide is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Contains an alkyne, allowing for conjugation through click chemistry. A basic building block for development of a protein degrader library.


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Sonstige Hinweise

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H360D
• P-Sätze: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Repr. 1B
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3