926027

NanoFabTX^™-DOTAP Lipid Mix

for synthesis of cationic (DOTAP) liposomes

• Synonym(e): Drug delivery, LNP, Microfluidics, NanoFab reagent kit, Nanoformulation, Nanoparticle
• UNSPSC-Code: 12162002
• NACRES: NA.23

Eigenschaften

• Qualitätsniveau: 100
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

NanoFabTx^™-DOTAP Lipid Mix includes reagents and optimized protocols with step-by-step instructions for synthesizing cationic liposomes for drug delivery research applications. The modification of liposomes with the cationic lipid, DOTAP, have numerous advantages such as their large-DNA incorporation, high transfection efficiency, and low toxicity. Liposome-based formulations are widely used for drug delivery applications and enable improved therapeutic efficacy of a range of drug types including small molecules, nucleic acids, proteins, and peptides.

Comprehensive protocols for liposome synthesis are included:

• A lipid film hydration and extrusion protocol.
• A microfluidics protocol using commercial platforms or syringe pumps.

The microfluidics protocol included with this product uses NanoFabTx^™ device kits (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Anwendung

NanoFabTx^™-DOTAP Lipid Mix is a ready-to-use nanoformulation blend for the synthesis of cationic DOTAP-functionalized liposomes. This kit enables users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. NanoFabTx^™ kits provide an easy-to-use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx^™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery.

Leistungsmerkmale und Vorteile

• A ready-to-use nanoformulation blend for the synthesis of cationic liposomes
• Step-by-step protocols (extrusion or microfluidic) developed and tested by our formulation scientists
• Flexible synthesis tools to create uniform and reproducible liposomes
• Optimized to make liposomes around 100 nm with low polydispersity
• DOTAP surface-functionalized allows for targeting ligand conjugation to enable targeted drug delivery

Rechtliche Hinweise

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3