910023

3,6,9,12,15,18-Hexaoxahexacos-25-ynoic acid

• Synonym(e): 2-2-2-2-2-2-6 PROTAC^® linker, Alkyne-PEG₆-acid, Bifunctional linker
• Empirische Formel (Hill-System): C₂₀H₃₆O₈
• Molekulargewicht: 404.50
• UNSPSC-Code: 12352106

Eigenschaften

• Form: liquid
• Eignung der Reaktion: reagent type: linker
• Funktionelle Gruppe: alkyne; carboxylic acid
• Lagertemp.: 2-8°C
• SMILES String: OC(COCCOCCOCCOCCOCCOCCCCCCC#C)=O

Beschreibung

Anwendung

This heterobifunctional, PEGylated crosslinker 3,6,9,12,15,18-hexaoxahexacos-25-ynoic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG₆-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-2-2-2-2-6.

Sonstige Hinweise

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Partial PROTACs for Targeted Protein Degradation

Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable