852678

6-Mercaptopurin Monohydrat

98%

• Synonym(e): 6-Purinthiol, 6-Thiohypoxanthin
• Empirische Formel (Hill-System): C₅H₄N₄S · H₂O
• CAS-Nummer: 6112-76-1
• Molekulargewicht: 170.19
• Beilstein: 4012091
• EG-Nummer: 200-037-4
• MDL-Nummer: MFCD03854445
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 24888330
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 98%
• Form: powder
• mp (Schmelzpunkt): >300 °C (lit.)
• SMILES String: O.Sc1ncnc2[nH]cnc12
• InChI: 1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2
• InChIKey: WFFQYWAAEWLHJC-UHFFFAOYSA-N
• Angaben zum Gen: human ... PPAT(5471)

Beschreibung

Allgemeine Beschreibung

6-Mercaptopurine monohydrate is an antimetabolite and antineoplastic drug. Its cocrystallization with 4-hydroxybenzoic acid and 2,4-dihydroxybenzoic acid or salt formation with piperazine may improve its aqueous solubility.

Anwendung

6-Mercaptopurine is a widely used antileukemic agent that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H301,H341,H361fd
• P-Sätze: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral - Muta. 2 - Repr. 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves