568600

6-Maleinimido-capronsäure-N-succinimidylester

98%

• Synonym(e): N-(ε-Maleinimidocaproyloxy)-succinimid, N-Succinimidyl-6-maleinimido-caproat, EMCS
• Empirische Formel (Hill-System): C₁₄H₁₆N₂O₆
• CAS-Nummer: 55750-63-5
• Molekulargewicht: 308.29
• Beilstein: 1499815
• MDL-Nummer: MFCD00043043
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24880215
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 98%
• Eignung der Reaktion: reagent type: cross-linking reagent
• mp (Schmelzpunkt): 70-73 °C (lit.)
• Funktionelle Gruppe: NHS ester; imide; maleimide
• Lagertemp.: −20°C
• SMILES String: O=C(ON(C(CC1)=O)C1=O)CCCCCN2C(C=CC2=O)=O
• InChI: 1S/C14H16N2O6/c17-10-5-6-11(18)15(10)9-3-1-2-4-14(21)22-16-12(19)7-8-13(16)20/h5-6H,1-4,7-9H2
• InChIKey: VLARLSIGSPVYHX-UHFFFAOYSA-N

Beschreibung

Anwendung

6-Maleimidohexanoic acid N-hydroxysuccinimide ester can be used in:

• Synthesis of maleimide-activated carbohydrates for site-specific glycosylation of cysteine-containing peptides and proteins via maleimide-thiol ligation reaction.
• Synthesis of a glucuronide prodrug of doxorubicin bearing a maleimide side chain as an antitumor agent.
• Cross-linking oligonucleotides with the amino groups on the substrate to fabricate DNA microarrays.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves