545872

(R)-(+)-Aminoglutethimid

97%

• Empirische Formel (Hill-System): C₁₃H₁₆N₂O₂
• CAS-Nummer: 55511-44-9
• Molekulargewicht: 232.28
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 24878857
• NACRES: NA.22

Eigenschaften

• Assay: 97%
• Optische Aktivität: [α]20/D +160°, c = 1 in methanol
• mp (Schmelzpunkt): 115.5-119.5 °C (lit.)
• SMILES String: CC[C@@]1(CCC(=O)NC1=O)c2ccc(N)cc2
• InChI: 1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)/t13-/m1/s1
• InChIKey: ROBVIMPUHSLWNV-CYBMUJFWSA-N
• Angaben zum Gen: human ... CYP17A1(1586) , CYP19A1(1588)

Beschreibung

Anwendung

(R)-(+)-Aminoglutethimide can be used:

• As a building block for the development of cephalosporin based prodrug for antibody-directed enzyme prodrug therapy (ADEPT).
• To prepare (R)-3-ethyl-3-(4-(3,4,5-trimethoxybenzylamino)phenyl)piperidine-2,6-dione by reacting with 3,4,5-trimethoxybenzylamine via deaminative coupling reaction.
• To synthesize (R)-2-fluoro-2-(4-methoxyphenyl)-N-(R)-(+)-aminoglutethimide by enantioselective α-fluorination.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves