473049

tert.-Butyl-(1S,4S)-(−)-2,5-diazabicyclo[2.2.1]heptan-2-carboxylat

95%

• Synonym(e): (1S,4S)-(−)-2-Boc-2,5-diazabicyclo[2.2.1]heptan
• Empirische Formel (Hill-System): C₁₀H₁₈N₂O₂
• CAS-Nummer: 113451-59-5
• Molekulargewicht: 198.26
• MDL-Nummer: MFCD01569250
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 24870862
• NACRES: NA.22

Eigenschaften

• Assay: 95%
• Optische Aktivität: [α]22/D −44°, c = 1 in chloroform
• mp (Schmelzpunkt): 74-76 °C (lit.)
• SMILES String: CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2
• InChI: 1S/C10H18N2O2/c1-10(2,3)14-9(13)12-6-7-4-8(12)5-11-7/h7-8,11H,4-6H2,1-3H3/t7-,8-/m0/s1
• InChIKey: UXAWXZDXVOYLII-YUMQZZPRSA-N

Beschreibung

Anwendung

(1S,4S)-(-)-2-Boc-2,5-diazabicyclo[2.2.1]heptane may be used in the preparation of 2-boc-5-(4-nitrophenyl)-2,5-diaza-bicyclo[2.2.1]heptane by reacting with p-nitrobenzene.
It may also be used to develop:

• indazolylpyrazolo[1,5-a]pyrimidine analogs based B-Raf inhibitors
• CCR2 antagonists
• α4β2 nicotinic acetylcholine receptor (nAChR) partial agonists
• azabicyclic sulfonamide based 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable