298891

(4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinon

99%

• Synonym(e): (4R,5S)-4-Methyl-5-phenyl-2-oxazolidinon
• Empirische Formel (Hill-System): C₁₀H₁₁NO₂
• CAS-Nummer: 77943-39-6
• Molekulargewicht: 177.20
• Beilstein: 1211705
• MDL-Nummer: MFCD00010845
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 24858003
• NACRES: NA.22

Eigenschaften

• Assay: 99%
• Form: solid
• Optische Aktivität: [α]18/D +168°, c = 2 in chloroform
• Optische Reinheit: ee: 98% (GLC)
• mp (Schmelzpunkt): 121-123 °C (lit.)
• SMILES String: C[C@H]1NC(=O)O[C@H]1c2ccccc2
• InChI: 1S/C10H11NO2/c1-7-9(13-10(12)11-7)8-5-3-2-4-6-8/h2-7,9H,1H3,(H,11,12)/t7-,9-/m1/s1
• InChIKey: PPIBJOQGAJBQDF-VXNVDRBHSA-N

Beschreibung

Anwendung

Evan′s chiral auxiliary (4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone reacts with carboxylic acids to produce corresponding acyl derivatives in the presence of a diisopropylcarbodiimide reagent. It can also employed in the preparation of N-sulfinyloxazolidinone reagent (chiral sulfinyl transfer reagent), which reacts with nucleophiles such as Grignard reagents, enolates, and metalated amides to produce the chiral sulfoxides, sulfinate esters, and sulfonamides.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)