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286044

Sigma-Aldrich

Harmin

98%

Synonym(e):

7-Methoxy-1-methyl-9H-pyrido[3,4-b]indol

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About This Item

Empirische Formel (Hill-System):
C13H12N2O
CAS-Nummer:
442-51-3
Molekulargewicht:
212.25
Beilstein:
178813
EG-Nummer:
207-131-4
MDL-Nummer:
MFCD00004958
UNSPSC-Code:
12352100
PubChem Substanz-ID:
24857229
NACRES:
NA.22

Assay

98%

mp (Schmelzpunkt)

262-264 °C (lit.)

SMILES String

CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3

InChI

1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3

InChIKey

BXNJHAXVSOCGBA-UHFFFAOYSA-N

Angaben zum Gen

human ... CDC2(983) , CYP2D6(1565)

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Allgemeine Beschreibung

The combination index (CI, serves as a quantitative indicator of pharmacological interactions) for harmaline/harmine and methylene blue/harmine was studied.

Anwendung

Harmine was used as a donor in the fluorescence resonance energy transfer (FRET) study between harmine and silver nanoparticles (AgNPs).

Biochem./physiol. Wirkung

Stimulant für das Zentralnervensystem

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Michael F Santillo et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(3), 403-410 (2014-01-01)
Interactions among monoamine oxidase (MAO) inhibitors in drugs, botanicals, and dietary supplements may lead to unpredictable neurochemical dysfunction due to excessive inhibition or therapeutic invalidation. Often recombinant MAO or brain tissue homogenates have been used to evaluate MAO inhibitors such
Katie L Uhl et al.
Cancer cell international, 18, 82-82 (2018-07-07)
Neuroblastoma (NB) is an early childhood malignancy that arises from the developing sympathetic nervous system. Harmine is a tricyclic β-carboline alkaloid isolated from the harmal plant that exhibits both cytostatic and cytotoxic effects. Harmine is capable of blocking the activities
Mansour Debdab et al.
Journal of medicinal chemistry, 54(12), 4172-4186 (2011-05-28)
We here report on the synthesis, optimization, and biological characterization of leucettines, a family of kinase inhibitors derived from the marine sponge leucettamine B. Stepwise synthesis of analogues starting from the natural structure, guided by activity testing on eight purified
Mohammad Amjadi et al.
Luminescence : the journal of biological and chemical luminescence, 29(6), 689-694 (2013-11-30)
This article reports on a novel fluorescence resonance energy transfer (FRET) system between harmine and silver nanoparticles (AgNPs), in which harmine acts as the donor and AgNPs act as the acceptor. As a result of FRET, harmine fluorescence is quenched
Jose A Morales-García et al.
Scientific reports, 7(1), 5309-5309 (2017-07-15)
Banisteriopsis caapi is the basic ingredient of ayahuasca, a psychotropic plant tea used in the Amazon for ritual and medicinal purposes, and by interested individuals worldwide. Animal studies and recent clinical research suggests that B. caapi preparations show antidepressant activity
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