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Sigma-Aldrich

Phosphonessigsäure

98%

Synonym(e):

(Carboxymethyl)phosphonic acid, 2-Phosphonoacetic acid, Fosfonoacetic acid, Phosphonacetic acid

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About This Item

Lineare Formel:
(HO)2P(O)CH2CO2H
CAS-Nummer:
4408-78-0
Molekulargewicht:
140.03
EG-Nummer:
224-558-1
MDL-Nummer:
MFCD00004311
UNSPSC-Code:
12352100
PubChem Substanz-ID:
24857145
NACRES:
NA.22

Assay

98%

Form

powder or crystals

mp (Schmelzpunkt)

143-146 °C (lit.)

Löslichkeit

water: soluble 100 mg/mL, clear to very slightly hazy, colorless

SMILES String

OC(=O)CP(O)(O)=O

InChI

1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7)

InChIKey

XUYJLQHKOGNDPB-UHFFFAOYSA-N

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Allgemeine Beschreibung

Phosphonoacetic acid inhibits specifically human cytomegalovirus DNA synthesis in virus-infected human fibroblasts. It also inhibits the synthesis of herpes simplex virus DNA in infected cells and the activity of the virus-specific DNA polymerase in vitro.

Anwendung

Phosphonoacetic acid was used as an inhibitor of viral DNA replication, to investigate the infected cell protein 0 (bICP0) localization in infected low passage bovine cells. It was also used as a phosphorus source for microbial growth in phosphate-independent manner.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Foscarnetnatrium United States Pharmacopeia (USP) Reference Standard

USP

1283302

Foscarnetnatrium

2-Aminoethylphosphonsäure 99%

Sigma-Aldrich

268674

2-Aminoethylphosphonsäure

Triphenylphosphat TraceCERT®, 31P-qNMR Standard, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

05498

Triphenylphosphat

Foscarnet-Natrium British Pharmacopoeia (BP) Reference Standard

BP623

Foscarnet-Natrium

L-(+)-2-Amino-3-Phosphonopropionsäure

Sigma-Aldrich

A154

L-(+)-2-Amino-3-Phosphonopropionsäure

R W Honess et al.
Journal of virology, 21(2), 584-600 (1977-02-01)
Phosphonoacetic acid (PAA) inhibited the synthesis of herpes simplex virus DNA in infected cells and the activity of the virus-specific DNA polymerase in vitro. In the presence of concentrations of PAA sufficient to prevent virus growth and virus DNA synthesis
Alireza Mahmoudian et al.
Comparative immunology, microbiology and infectious diseases, 35(2), 103-115 (2011-12-27)
The kinetics of expression of only a few genes of infectious laryngotracheitis virus (ILTV) have been determined, using northern blot analysis. We used quantitative reverse transcriptase PCR to examine the kinetics of expression of 74 ILTV genes in LMH cells.
E S Huang
Journal of virology, 16(6), 1560-1565 (1975-12-01)
Phosphonoacetic acid specifically inhibited human cytomegalovirus DNA synthesis in virus-infected human fibroblasts as detected by virus-specific nucleic acid hybridization. Inhibition was reversible; viral DNA synthesis resumed upon the removal of the drug. The compound partially inhibited DNA synthesis of host
Jacqueline P Smits et al.
The Journal of organic chemistry, 76(21), 8807-8813 (2011-09-16)
The α-trisphosphonic acid esters provide a unique spatial arrangement of three phosphonate groups and may represent an attractive motif for inhibitors of enzymes that utilize di- or triphosphate substrates. To advance studies of this unique functionality, a general route to
Magdalena Klimek-Ochab
Folia microbiologica, 59(5), 375-380 (2014-02-27)
A psychrophilic fungal strain of Geomyces pannorum P15 was screened for its ability to utilize a range of synthetic and natural organophosphonate compounds as the sole source of phosphorus, nitrogen, or carbon. Only phosphonoacetic acid served as a phosphorus source
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