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Merck

HIRA

histone cell cycle regulator

Synonyme:
DGCR1, TUP1, TUPLE1
Spezies:
Human HIRA (7290), Mouse Hira (15260), Rat Hira (363849), Zebrafish hira (568076), fruit fly Hira (31680), cow HIRA (511514), Horse HIRA (100052845), domestic cat HIRA (101098170), dog HIRA (486424), Thale Cress HIRA (823578) ...Mehr
UniProtKB-ID:
P54198, Q05BU9, Q8IXN2
Gen-ID:
  • Human(7290) Summary: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
  • Mouse(15260) histone cell cycle regulation defective homolog A (S. cerevisiae)
  • Rat(363849) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • Zebrafish(568076) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • fruit fly(31680) CG12153 gene product from transcript CG12153-RA
  • cow(511514) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • Horse(100052845) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • domestic cat(101098170) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • dog(486424) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • Thale Cress(823578) protein HIRA
  • chicken(374074) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • sheep(101120607) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • Domestic Rabbit(100352472) HIR histone cell cycle regulation defective homolog A (S. cerevisiae)

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Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
04-1488
Anti-HIRA-Antikörper, Klon WC119, clone WC119, from mouse,
Speziesreaktivität
human, mouse
Anwendung
immunoprecipitation (IP)
western blot
HPA052902
Anti-HIRA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Speziesreaktivität
human
Anwendung
immunofluorescence
HPA050714
Anti-HIRA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
SAB1300755
Anti-HIRA (center) antibody produced in rabbit, saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
ELISA
western blot
SAB1400286
Anti-HIRA antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
immunofluorescence
western blot

esiRNA

Produktnummer
Beschreibung
Spezies
EHU061801
MISSION® esiRNA, targeting human HIRA, C22ORF39,
Spezies
human
EMU032731
MISSION® esiRNA, targeting mouse Hira,
Spezies
mouse