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T7687

Sigma-Aldrich

Anti-Tissue Inhibitor of Metalloproteinase-3, First Loop antibody produced in rabbit

~1 mg/mL, buffered aqueous glycerol solution, affinity isolated antibody

Synonym(s):

Anti-TIMP-3

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About This Item

MDL number:
MFCD01634335
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: 1:1,000 using a whole cell extract from human fibroblasts (M 3303)

UniProt accession no.

P35625

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TIMP3(7078)

Specificity

By immunoblotting against the reduced protein, the antibody reacts with bands at ~24 kDa and 30 kDa (unglycosylated and glycosylated, respectively). It also reacts with non-reduced TIMP-3.

Immunogen

synthetic peptide corresponding to the first loop of human tissue inhibitor of metalloproteinase-3.

Physical form

Solution in phosphate buffered saline, pH 7.4, containing 50% glycerol and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H319,H334

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Christine E Arris et al.
Biochimica et biophysica acta, 1638(1), 20-28 (2003-05-22)
Gingival fibroblast cell lines were derived from Sorsby's fundus dystrophy (SFD) patients carrying the S181C TIMP3 and the E139X TIMP3 mutations. These cell lines were grown in culture to study expression of the wild-type and mutant tissue inhibitor of metalloproteinase
Z Saihan et al.
Molecular vision, 15, 1218-1230 (2009-06-19)
To determine the phenotypic and biochemical characteristics of the p.E139K missense variant in tissue inhibitor of metalloproteinase 3 (TIMP3) associated with Sorsby fundus dystrophy (SFD). The coding regions and adjacent intronic sequence of TIMP3 were amplified by polymerase chain reaction
David E Robinson et al.
Biomaterials, 33(4), 1007-1016 (2011-11-15)
Glycosaminoglycans play an important role in tissue organisation through interactions with a diverse range of proteins, growth factors and other chemokines. In this report, we demonstrate the GAG-binding 'fingerprint' of two important GAG-binding proteins - osteoprotogerin and TIMP-3. The technique
Sarah Naessens et al.
Human mutation, 40(5), 539-551 (2019-01-23)
Sorsby fundus dystrophy (SFD) is a macular degeneration caused by mutations in TIMP3, the majority of which introduce a novel cysteine. However, the exact molecular mechanisms underlying SFD remain unknown. We aimed to provide novel insights into the functional consequences

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