T5134
(±)-α-Tocopherol nicotinate
Synonym(s):
Vitamin E nicotinate
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About This Item
Empirical Formula (Hill Notation):
C35H53NO3
CAS Number:
Molecular Weight:
535.80
EC Number:
MDL number:
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.79
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Assay
≥98%
Quality Level
form
solid or liquid
color
white to yellow
storage temp.
2-8°C
SMILES string
CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)c3cccnc3)c(C)c(C)c2O1
InChI
1S/C35H53NO3/c1-24(2)13-9-14-25(3)15-10-16-26(4)17-11-20-35(8)21-19-31-29(7)32(27(5)28(6)33(31)39-35)38-34(37)30-18-12-22-36-23-30/h12,18,22-26H,9-11,13-17,19-21H2,1-8H3/t25-,26-,35-/m1/s1
InChI key
MSCCTZZBYHQMQJ-AZAGJHQNSA-N
Related Categories
General description
α-Tocopherol nicotinate is a fat soluble vitamin. It is an ester of tocopherol and niacin. Niacin is linked to the hydroxyl group of active vitamin E in this ester. α-Tocopherol is a form of vitamin E, which is available through dietary sources. RRR-α-tocopherol is a natural form of α-Tocopherol.
Application
(±)-α-Tocopherol nicotinate has been used in metabolic studies to assess its biological functions in rats.
Biochem/physiol Actions
α-Tocopherol is a radical-chain breaker owing to its anti-oxidant property.
Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. α-Tocopherol nicotinate is used along the α-Tocopherol acetate, α-Tocopherol succinate and other esterified forms as a vitamin E supplement with similar but differential activities.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Tocopherols, tocotrienols and tocomonoenols: Many similar molecules but only one vitamin E
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K N Prasad et al.
Cancer research, 42(2), 550-555 (1982-02-01)
The effects of various forms of tocopherol (vitamin E) on the growth and differentiation of mouse melanoma (B-16) and mouse fibroblast (L-cells) cells in culture were studied. D-alpha-tocopherol acid succinate induced morphological alterations and growth inhibition in melanoma cells. When
A Funakoshi et al.
The Tohoku journal of experimental medicine, 148(4), 393-401 (1986-04-01)
The fasting serum levels of alpha-tocopherol were determined by high-pressure liquid chromatography in 13 patients with chronic pancreatitis of whom 7 were positive for pancreatic calcification (CCP) and 6, negative (NCP) and 10 healthy subjects. The fasting serum levels of
N Inagaki et al.
Journal of pharmacobio-dynamics, 7(1), 70-74 (1984-01-01)
Effect of vitamin E (alpha-tocopheryl acetate and alpha-tocopheryl nicotinate) on IgE antibody formation in mice was investgiated . Female BALB/c mice were immunized with dinitrophenylated ascaris protein (DNP-As) and aluminium hydroxide gel (alum). Supplementation of vitamin E in diets or
T W Chung et al.
Diabetic medicine : a journal of the British Diabetic Association, 15(5), 380-385 (1998-06-03)
The effects of alpha-tocopherol nicotinate on blood viscoelasticity and viscosity and on lipid peroxidation stress in erythrocyte membranes in patients with Type 2 DM were investigated. Thirteen Type 2 diabetic subjects with retinopathy were given alpha-tocopherol nicotinate 300 mg tds
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