SML3556
Compound 18
≥98% (HPLC)
Synonym(s):
MPO-IN-28, N-(7-Methoxy-4-methyl-2-quinazolinyl)guanidine
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About This Item
Empirical Formula (Hill Notation):
C11H13N5O
CAS Number:
Molecular Weight:
231.25
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
Biochem/physiol Actions
Compound 18 is an agonist of Aedes aegypti mosquitoes NPY-like receptor 7 (NPYLR7) that inhibit mosquito attraction to humans and other hosts. Compound 18 suppresses biting and blood-feeding on a live host. Also, It (MPO-IN-28) is a potent myeloperoxidase (MPO) inhibitor with an IC50 of 44 nM.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Laura B Duvall et al.
Cell, 176(4), 687-701 (2019-02-09)
Female Aedes aegypti mosquitoes bite humans to obtain blood to develop their eggs. Remarkably, their strong attraction to humans is suppressed for days after the blood meal by an unknown mechanism. We investigated a role for neuropeptide Y (NPY)-related signaling
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