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SML2667

Sigma-Aldrich

AC261066

≥98% (HPLC)

Synonym(s):

4-[4-(2-Butoxyethoxy)-5-methyl-2-thiazolyl]-2-fluorobenzoic acid, AC 261066, AC-261066

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About This Item

Empirical Formula (Hill Notation):
C17H20FNO4S
CAS Number:
870773-76-5
Molecular Weight:
353.41
MDL number:
MFCD18086924
UNSPSC Code:
12352200

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C17H20FNO4S/c1-3-4-7-22-8-9-23-15-11(2)24-16(19-15)12-5-6-13(17(20)21)14(18)10-12/h5-6,10H,3-4,7-9H2,1-2H3,(H,20,21)

InChI key

HSAOETBFVAWNRP-UHFFFAOYSA-N

Biochem/physiol Actions

AC261066 is an orally active, selective and potent synthetic agonist for the retinoic acid β2-receptor (RARβ2) that decreases oxidative stress in mice fed a high-fat diet. AC261066 reduce ischemia/reperfusion injury of the heart in mice models.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alice Marino et al.
The Journal of pharmacology and experimental therapeutics, 366(2), 314-321 (2018-06-17)
We previously discovered that oral treatment with AC261066, a synthetic selective agonist for the retinoic acid β2-receptor, decreases oxidative stress in the liver, pancreas, and kidney of mice fed a high-fat diet (HFD). Since hyperlipidemic states are causally associated with
Birgitte W Lund et al.
Journal of medicinal chemistry, 48(24), 7517-7519 (2005-11-24)
4'-Octyl-4-biphenylcarboxylic acid (1g, AC-55649) was identified as a highly isoform-selective agonist at the human RARbeta2 receptor in a functional intact cell-based screening assay. The subsequent hit to lead optimization transformed the lipophilic, poorly soluble hit into a more potent and
Steven E Trasino et al.
Journal of molecular medicine (Berlin, Germany), 94(10), 1143-1151 (2016-06-09)
Hepatic stellate cells (HSCs) are an important cellular target for the development of novel pharmacological therapies to prevent and treat nonalcoholic fatty liver diseases (NAFLD). Using a high fat diet (HFD) model of NAFLD, we sought to determine if synthetic

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