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SML2193

Sigma-Aldrich

Altenusin

≥98% (HPLC)

Synonym(s):

3,4′,5′-Trihydroxy-5-methoxy-2′-methyl[1,1′-biphenyl]-2-carboxylic acid, Alutenusin

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About This Item

Empirical Formula (Hill Notation):
C15H14O6
CAS Number:
31186-12-6
Molecular Weight:
290.27
UNSPSC Code:
12352200
NACRES:
NA.77

biological source

Penicillium sp.

Assay

≥98% (HPLC)

form

powder

color

yellow to orange

storage temp.

−20°C

SMILES string

OC1=CC(C2=CC(OC)=CC(O)=C2C(O)=O)=C(C)C=C1O

InChI

1S/C15H14O6/c1-8-5-13(16)14(17)7-11(8)12-6-9(20-2)3-4-10(12)15(18)21-19/h3-7,16-17,19H,1-2H3

InChI key

GWGIZSANXIQQQR-UHFFFAOYSA-N

Biochem/physiol Actions

Altenusin, a non-steroidal fungal metabolite, is a potent and selective agonist of Farnesoid X receptor (FXR) that protects mice from high-fat diet induced obesity. Also it decreases blood glucose level, serum insulin level, and reduces lipid droplets accumulation. Altenusin inhibits trypanothione reductase from Trypanosoma cruzi.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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FEMS microbiology letters, 285(2), 177-182 (2008-06-19)
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