SML0922
NSC130813
≥98% (HPLC)
Synonym(s):
4-[(6-Chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-phenol trihydrochloride, F06, NERI02
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About This Item
Empirical Formula (Hill Notation):
C26H27ClN4O2 · 3HCl
CAS Number:
Molecular Weight:
572.35
UNSPSC Code:
51111800
NACRES:
NA.77
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
H2O: 10 mg/mL, clear
storage temp.
−20°C
Biochem/physiol Actions
NSC130813 blocks protein-protein interactions between XPF and ERCC1, two proteins involved in nucleotide excision repair (NER). The compound, NSC130813, blocks repair of DNA damage induced by platinum-based ctyotoxic drugs and DNA alkylating agents. NSC130813 synergistically potentiates cell death in cancer cell lines treated with cisplatin or mitomycin C.
Other Notes
air sensitive
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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