SAB4300684

Anti-phospho-Cyclin E1 (pThr³⁹⁵) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-CCNE, Anti-CCNE1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~48 kDa
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (L-L-Tp-P-P)
• NCBI accession no.: NM_001238.1
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pThr395)
• Gene Information: human ... CCNE1(898)

Description

General description

The antibody detects endogenous level of Cyclin E1 only when phosphorylated at threonine 395.

Immunogen

Peptide sequence around phosphorylation site of threonine 395 (L-L-Tp-P-P), according to the protein NP_001229.1

Features and Benefits

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Target description

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable