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Key Documents

SAB2501384

Sigma-Aldrich

Anti-CSF1R antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-C-FMS, Anti-CD115, Anti-CSFR, Anti-FIM2, Colony stimulating factor 1 receptor

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

canine, rat, human, mouse

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P07333

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CSF1R(1436)

General description

CSF1R (colony stimulating factor 1 receptor) or FMS, acts as a receptor for CSF1, and regulates monocyte and macrophage functioning. It is a member of the platelet-derived growth factor (PDGF) family of proteins, and is a type III RTK (receptor tyrosine kinase). CSF1R is composed of five immunoglobulin (Ig)-like domains, a transmembrane region, a juxtamembrane domain and kinase insert domain (KID) intersecting the kinase domain.

Immunogen

Peptide with sequence KNIHLEKKYVR, from the internal region of the protein sequence according to NP_005202.2

Biochem/physiol Actions

CSF1R (colony stimulating factor 1 receptor), and its ligand CSF1 are linked to poor prognosis in patients with solid tumors, and in patients with female reproductive cancers. In breast cancers, with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGFβ (tumor growth factor β). Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Haploinsufficiency of CSF-1R and clinicopathologic characterization in patients with HDLS.
Konno T
Neurology (2014)
Autocrine CSF1R signaling mediates switching between invasion and proliferation downstream of TGF? in claudin-low breast tumor cells.
Patsialou A
Oncogene (2015)
Chromatin-associated CSF-1R binds to the promoter of proliferation-related genes in breast cancer cells.
Barbetti V
Oncogene (2014)
CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function.
Pridans C
Scientific Reports (2013)
Myew-Ling Toh et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(11), 2989-3000 (2014-03-14)
Colony-stimulating factor 1 receptor (CSF-1R) essentially modulates monocyte proliferation, migration, and activation, which are considered important for the pathogenesis of rheumatoid arthritis (RA). We undertook this study to determine CSF-1R expression in human RA as well as the efficacy of
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