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S5076

Sigma-Aldrich

SF-22

≥98% (HPLC)

Synonym(s):

N-[1,1′-Biphenyl]-2-yl-3-[[(2,5-dimethylphenyl)amino]sulfonyl]-4-methyl-benzamide, SID 17413034

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About This Item

Empirical Formula (Hill Notation):
C28H26N2O3S
CAS Number:
824981-55-7
Molecular Weight:
470.58
MDL number:
MFCD06623281
UNSPSC Code:
12352200
PubChem Substance ID:
329824449
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

solubility

DMSO: 26 mg/mL

storage temp.

room temp

SMILES string

Cc1ccc(C)c(NS(=O)(=O)c2cc(ccc2C)C(=O)Nc3ccccc3-c4ccccc4)c1

InChI

1S/C28H26N2O3S/c1-19-13-14-20(2)26(17-19)30-34(32,33)27-18-23(16-15-21(27)3)28(31)29-25-12-8-7-11-24(25)22-9-5-4-6-10-22/h4-18,30H,1-3H3,(H,29,31)

InChI key

BWWPVIRXNOWQSI-UHFFFAOYSA-N

Application

SF-22 may be used in NPY Y2 receptor-mediated studies.

Biochem/physiol Actions

Radioligand studies reveal that SF-22 also targets 5-HT2B and 5-HT6 serotonin receptors and dopamine transporter.1
SF-22 is a potent, selective NPY Y2 receptor antagonist; highly brain-penetrant

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Shaun P Brothers et al.
Molecular pharmacology, 77(1), 46-57 (2009-10-20)
The role of neuropeptide Y Y2 receptor (Y2R) in human diseases such as obesity, mood disorders, and alcoholism could be better resolved by the use of small-molecule chemical probes that are substantially different from the currently available Y2R antagonist, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide)
Xinghua Feng et al.
Cell calcium, 56(6), 446-456 (2014-10-01)
Mucolipin synthetic agonist 1 (ML-SA1) was recently identified to activate mammalian TRPML channels and shown to alleviate lipid accumulation in lysosomes of cellular models of lysosome storage diseases, mucolipidosis type IV (MLIV) and Niemann-Pick's disease type C (NPC). Owning to

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