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S4447

Sigma-Aldrich

α-Synuclein E46K human

recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder

Synonym(s):

NACP (Non-a-beta component of Alzheimer disease amyloid, precursor), PARK1, PARK4, PD1, non A4 component of amyloid precursor

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

recombinant

expressed in E. coli

Quality Level

200

Assay

≥90% (SDS-PAGE)

form

lyophilized powder

mol wt

apparent mol wt 19-20 kDa

UniProt accession no.

P37840

compatibility

for use with ABI StepOnePlus

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... SNCA(6622)

Biochem/physiol Actions

Among the familial mutations of α-synuclein in Parkinson′s disease, E46K has the greatest potential to aggregate. This mutation is a 188G-A tran­sition resulting in a Glu46-to-Lys (E46K) substitution in the amino-terminal region of the protein.
Deposition of α-synuclein as fibrillary tangles is a hallmark of certain neurodegenerative diseases including Parkinson′s. Among the familial mutations of α-synuclein, E46K has the greatest potential to aggregate.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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