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I6284

Sigma-Aldrich

Anti-Human IgE (ε-chain specific) antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti Human Ige, Anti-Human IgE - Anti-Human IgE (ε-chain specific) antibody produced in goat, Anti-Human Ige

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About This Item

MDL number:
MFCD00162427
UNSPSC Code:
12352203
NACRES:
NA.46

biological source

goat

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

secondary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

Ouchterlony double diffusion: suitable

storage temp.

2-8°C

target post-translational modification

unmodified

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General description

IgE is a class of immunoglobulins that is produced only in mammals. IgE is secreted by mast cells in response to allergens and is important in immunity against parasites. It also is the most important factor in the pathophysiology of anaphylaxis or type I hypersensitivity. The antibody preparation is specific for human IgE when tested against purified human IgA, IgG, IgM, Bence Jones κ, and Bence Jones λ proteins. Identity and purity of the antibody is established by immunoelectrophoresis.

Immunogen

Purified human IgE (myeloma)

Application

Anti-Human IgE (epsilon-chain specific) antibody may be used as a control in various immunoassays.

Physical form

Lyophilized from 0.01 M sodium phosphate, 0.015 M sodium chloride, pH 7.2.

Reconstitution

Reconstitute with 0.135 M sodium chloride to achieve a 1 mg/mL solution of antibody.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Shiteng Duan et al.
The Journal of clinical investigation, 129(3), 1387-1401 (2019-01-16)
Allergen immunotherapy for patients with allergies begins with weekly escalating doses of allergen under medical supervision to monitor and treat IgE mast cell-mediated anaphylaxis. There is currently no treatment to safely desensitize mast cells to enable robust allergen immunotherapy with
Bettina Wedi et al.
Allergy, 75(9), 2229-2242 (2020-02-01)
Mas-related G protein-coupled receptor X2 (MRGPRX2) is regarded as a mast cell-specific receptor mediating non-IgE-dependent activation. We aimed to investigate whether human basophils and eosinophils express functional MRGPRX2. Flow cytometry, immunocytochemistry, immunofluorescence, Western blot, and RT-PCR were performed in highly
Stephen J Galli et al.
Nature medicine, 18(5), 693-704 (2012-05-09)
Immunoglobulin E (IgE) antibodies and mast cells have been so convincingly linked to the pathophysiology of anaphylaxis and other acute allergic reactions that it can be difficult to think of them in other contexts. However, a large body of evidence
Jie Zhao et al.
mAbs, 11(5), 837-847 (2019-04-06)
Asthma is characterized by airway hyperresponsiveness and inflammation, as well as underlying structural changes to the airways. Interleukin-4 (IL-4) is a key T-helper type 2 (Th2) cytokine that plays important roles in the pathogenesis of atopic and eosinophilic asthma. We
Minjae Kim et al.
Journal of immunology (Baltimore, Md. : 1950), 208(3), 772-779 (2022-01-14)
Human IgE is useful for immunological assays, such as sensitization of FcεRI-positive cells and IgE measurement. In this study, we report the development of a recombinant Ig fragment, designated IgCw-γεκ, as an alternative reagent to human IgE. IgCw-γεκ (∼130 kDa)

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Anti-Human Antibodies for COVID-19 (SARS-CoV-2) Immunoglobulin Detection Research

Antibody-based serology tests are useful in identifying subjects with an adaptive immune response to the SARS-CoV-2 virus. Anti-human immunoglobulin antibodies allow for quick and simple, yet reliable assays with easy readouts and can also be adapted for high-throughput screening.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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