I4909

Ifosfamide

≥98%

• Synonym(s): Ifex, N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide
• Empirical Formula (Hill Notation): C₇H₁₅Cl₂N₂O₂P
• CAS Number: 3778-73-2
• Molecular Weight: 261.09
• EC Number: 223-237-3
• MDL number: MFCD00057374
• UNSPSC Code: 41116107
• PubChem Substance ID: 329815378
• NACRES: NA.25

Properties

• Assay: ≥98%
• shipped in: wet ice
• storage temp.: 2-8°C
• SMILES string: ClCCNP1(=O)OCCCN1CCCl
• InChI: 1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)
• InChI key: HOMGKSMUEGBAAB-UHFFFAOYSA-N

Description

Application

• Ewing sarcoma of the pancreas: a pediatric case report and narrative literature review: This study explores the effectiveness of Ifosfamide in the treatment of rare pediatric Ewing sarcoma of the pancreas, providing valuable insights into the chemotherapeutic management of rare cancers (Liu et al., 2024).


• Prognostic value of hemogram parameters in osteosarcoma: The French OS2006 experience: Highlights the role of Ifosfamide in osteosarcoma treatment as part of a clinical trial, evaluating its impact on survival rates and treatment outcomes (Bastard et al., 2024).


• Case report: Characteristics and nature of primary cardiac synovial sarcoma: Discusses the utilization of Ifosfamide in managing primary cardiac synovial sarcoma, with an emphasis on its pharmacodynamics and therapeutic efficacy (Kawasaki et al., 2024).


• Dedifferentiated liposarcoma of the spermatic cord: Examines Ifosfamide′s mechanism of action in treating dedifferentiated liposarcoma, contributing to the broader understanding of its application in sarcoma therapy (Panther et al., 2024).


• A Rare Case of Extranodal Natural Killer/T-cell Lymphoma, Nasal Type Associated With Hemophagocytic Lymphohistiocytosis in a Patient With Recurrent Sinusitis: This article details the clinical use of Ifosfamide in treating aggressive lymphoma, underscoring its role in complex cases where standard treatments may not suffice (Christensen et al., 2024).

Biochem/physiol Actions

Ifosfamide is a nitrogen mustard compound that is a structural isomer of cyclophosphamide. Ifosfamide is a prodrug that must be transformed by cytochrome P450 to the biologically active component. It is used as an antineoplastic agent in cancer chemotherapy, but ifosfamide is more likely to cause renal toxicity than cyclophosphamide.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H301,H319,H340,H350,H360FD
• Precautionary Statements: P202 - P264 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves