Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

D8941

Sigma-Aldrich

2,6-Difluoro-4-[2-(phenylsul­fonyl­amino)­ethyl­thio]­phenoxy­acet­amide

≥98% (HPLC), solid

Synonym(s):

PEPA

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C16H16N2O4S2F2
CAS Number:
141286-78-4
Molecular Weight:
402.44
MDL number:
MFCD04974493
UNSPSC Code:
12352200
PubChem Substance ID:
24278571
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

white

solubility

DMSO: >20 mg/mL

SMILES string

NC(=O)COc1c(F)cc(SCCNS(=O)(=O)c2ccccc2)cc1F

InChI

1S/C16H16F2N2O4S2/c17-13-8-11(9-14(18)16(13)24-10-15(19)21)25-7-6-20-26(22,23)12-4-2-1-3-5-12/h1-5,8-9,20H,6-7,10H2,(H2,19,21)

InChI key

GTACSIONMHMRPD-UHFFFAOYSA-N

Gene Information

human ... GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893)

Biochem/physiol Actions

2,6-Difluoro-4-[2-(phenylsul­fonyl­amino)­ethyl­thio]­phenoxy­acet­amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Amirbek Bekeshev et al.
Polymers, 12(7) (2020-07-02)
The conducted studies have proven the possibility of the directed control of operational properties of epoxy composites, due to the addition of finely-ground ocher into their composition, and the use of microwave modification of the epoxy composition. The rational content
Weisheng Chen et al.
Neuroscience letters, 612, 126-131 (2015-12-08)
Infralimbic cortex (IL) is proposed to suppress cocaine seeking after extinction, but whether the IL regulates the extinction and reinstatement of heroin-seeking behavior is unknown. To address this issue, the male SD rats were trained to self-administer heroin under a
Quan-Guang Zhang et al.
Hippocampus, 20(1), 65-77 (2009-03-31)
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are responsible for excitotoxicity induced by ischemic injury in hippocampal CA1 neurons, whereas the molecular mechanisms responsible for their neurotrophic activities are much less studied. Here, we examined the neuroprotective effect of positive modeulation of AMPARs
Yanchao Xu et al.
Journal of colloid and interface science, 565, 23-34 (2020-01-14)
Nanofiltration (NF) membranes with tannic acid (TA) based selective layers have been intensively studied in recent years, but they still suffer from poor inorganic salt rejection. This study provided a first report on mussel-inspired co-deposition of TA and amine to
Mary L Huff et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(4), 861-873 (2014-09-27)
Recent findings suggest that the mesolimbic dopamine neurons, known to promote cocaine-seeking behavior, are strongly inhibited by a newly characterized region of the midbrain known as the rostromedial tegmental nucleus (RMTg). The RMTg appears to be involved in generating reward-prediction
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service