B9806
Heparin−biotin sodium salt
≥97%
Synonym(s):
Heparin-Biotin Conjugate
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About This Item
Recommended Products
conjugate
biotin conjugate
Quality Level
Assay
≥97%
form
solid
mol wt
~15000 Da
solubility
H2O: soluble 1 mg/mL, clear, colorless
storage temp.
2-8°C
Application
Heparin-biotin is used transfection research for the development of self-assembled terplexes such as polyamidoamine dendrimer and DNA (PAMAM/DNA) heparin-biotin terplexes for targeted gene delivery with improved transfection. The terplexes may be used in immobilizing proteins such as lactoferrin and lysozyme and nucleic acids.
Other Notes
Biotin conjugated to heparin from porcine intestinal mucosa
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Conjugation of polyamidoamine dendrimers on biodegradable microparticles for nonviral gene delivery.
Xue-Qing Zhang et al.
Bioconjugate chemistry, 18(6), 2068-2076 (2007-09-13)
We report on the preparation and characterization of poly(D, L-lactide-co-glycolide) (PLGA) microparticles with surface-conjugated polyamidoamine (PAMAM) dendrimers of varying generations. The buffering capacity and zeta-potential of the PLGA PAMAM microparticles increased with increasing generation level of the PAMAM dendrimer conjugated.
Nan Liu et al.
Die Pharmazie, 67(2), 174-181 (2012-04-20)
The efficiency and safety of gene delivery vectors were important factors for gene therapy. To enhance gene transfection efficiency and to incorporate biocompatible components to the polyamidoamine (PAMAM) dendrimer mediated gene delivery systems, human serum albumin (HSA) was introduced to
Dzmitry Shcharbin et al.
Journal of controlled release : official journal of the Controlled Release Society, 141(2), 110-127 (2009-10-10)
This paper reviews different techniques for analyzing the transfection efficiencies and cytotoxicities of dendriplexes-complexes of nucleic acids with dendrimers. Analysis shows that three plasmids are mainly used in transfection experiments: plasmid DNA encoding luciferase from the firefly Photinus pyralis, beta-galactosidase
Kelly M Kitchens et al.
Advanced drug delivery reviews, 57(15), 2163-2176 (2005-11-18)
This article summarizes our efforts to evaluate the potential of poly (amidoamine) (PAMAM) dendrimers as carriers for oral drug delivery. Specifically, the permeability of a series of cationic PAMAM-NH2 (G0-G4) dendrimers across Caco-2 cell monolayers was evaluated as a function
Qiao Zhang et al.
Bioconjugate chemistry, 21(11), 2086-2092 (2010-10-12)
To improve transfection efficiency and to incorporate target ligands to the gene delivery systems, heparin and heparin-biotin were introduced to complexes of polyamidoamine dendrimer and DNA (PAMAM/DNA) via electrostatic interactions to form self-assembled PAMAM/DNA/heparin and PAMAM/DNA/heparin-biotin terplexes, respectively. The self-assembled
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