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46148

Supelco

Corticosterone

VETRANAL®, analytical standard

Synonym(s):

11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H

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About This Item

Empirical Formula (Hill Notation):
C21H30O4
CAS Number:
50-22-6
Molecular Weight:
346.46
Beilstein:
2339601
EC Number:
200-019-6
MDL number:
MFCD00037715
UNSPSC Code:
41116107
PubChem Substance ID:
329757087
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

Assay

≥98% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

179-183 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI key

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

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General description

Corticosterone is one of the principal steroids secreted by the rat adrenal gland and found in rat plasma.

Application

Corticosterone may be used as a reference standard in the determination of corticosterone in plasma samples using high-performance liquid chromatography (HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG5805
BCCC8243
BCBT8610
SZBC066XV
SZB7141XV

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Determination of plasma corticosterone using high-performance liquid chromatography.
Woodward HJC and Emery WP
Journal of Chromatography. B, Biomedical Sciences and Applications, 419(2), 280-284 (1987)
The estimation of small amounts of corticosterone in rat plasma.
Zenker N and Bernstein ED
The Journal of Biological Chemistry, 231(2), 695-701 (1958)
Kirsten R Jacobsen et al.
Comparative medicine, 63(2), 105-113 (2013-04-16)
Laboratory mice constitute an extensively used model to study the pathologic and functional outcomes of cerebral ischemic stroke. The middle cerebral artery occlusion (MCAO) model requires surgical intervention, which potentially can result in postsurgical pain and stress. In the present
Selective retention of corticosterone by limbic structures in rat brain.
McEwen SB, et al.
Nature, 220(5170), 911-911 (1968)
Damiano Azzinnari et al.
Neuropharmacology, 85, 328-341 (2014-06-08)
In neuropsychiatry, animal studies demonstrating causal effects of environmental manipulations relevant to human aetiology on behaviours relevant to human psychopathologies are valuable. Such valid models can improve understanding of aetio-pathophysiology and preclinical discovery and development of new treatments. In depression
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