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AB5930

Sigma-Aldrich

Anti-Potassium Channel ERG1 Antibody, CT

Chemicon®, from rabbit

Synonym(s):

Ether-a-go-go-related Gene Product, HERG1, MERG1, RERG1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse, rat

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NM_000238.2
NM_172056.1
NM_172057.1

UniProt accession no.

Q12809

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... KCNH2(3757)

General description

ERG1 encodes the pore forming alpha subunit of the voltage-gated channels that conduct the rapid delayed rectifier potassium current, which leads to termination of the cardiac ventricular action potential. A large number of commercially available therapeutic agents (antiarrhythmics, antihistamines, antibiotics and antidepressants) have been shown to preferentially block ERG1 and cause a disorder of cardiac action potential depolarization that predisposes affected individuals to ventricular arrhythmia and sudden death.

Specificity

ERG1 protein. By western blot, antibody recognizes bands at 175 and 205 kDa (glycosylated) or 135 and 165 kDa (deglycosylated).

Immunogen

Epitope: C-terminus
Synthetic peptide corresponding to the C-terminus of ERG1 (aa 1145-1159 of HERG1).

Application

Anti-Potassium Channel ERG1 Antibody, C-terminus detects level of Potassium Channel ERG1 & has been published & validated for use in IC, IH, IP & WB.
Immunoblotting: 5 μg/mL

Immunocytochemistry

Immunohistochemistry on 4% paraformaldehyde fixed tissues.

Immunoprecipitation

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters

Physical form

Liquid in PBS with 0.1% sodium azide.

Storage and Stability

Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles

Analysis Note

Control
Positive control tissue: Heart

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A L Pond et al.
The Journal of biological chemistry, 275(8), 5997-6006 (2000-02-22)
One form of inherited long QT syndrome, LQT2, results from mutations in HERG1, the human ether-a-go-go-related gene, which encodes a voltage-gated K(+) channel alpha subunit. Heterologous expression of HERG1 gives rise to K(+) currents that are similar (but not identical)
CD31 delays phagocyte membrane repolarization to promote efficient binding of apoptotic cells.
Vernon-Wilson, EF; Aurade, F; Tian, L; Rowe, IC; Shipston, MJ; Savill, J; Brown, SB
Journal of Leukocyte Biology null
Sönke Cordeiro et al.
PloS one, 6(12), e29490-e29490 (2011-12-30)
In response to light, most retinal neurons exhibit gradual changes in membrane potential. Therefore K+ channels that mediate threshold currents are well-suited for the fine-tuning of signal transduction. In the present study we demonstrate the expression of the different Kv11

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