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T-058

Supelco

Tapentadol hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

Tapentadol hydrochloride solution

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About This Item

Empirical Formula (Hill Notation):
C14H23NO · HCl
CAS Number:
175591-09-0
Molecular Weight:
257.80
EC Number:
200-659-6
MDL number:
MFCD00944992
UNSPSC Code:
41116107
PubChem Substance ID:
329826275
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

Cl.CC[C@H]([C@@H](C)CN(C)C)c1cccc(O)c1

InChI

1S/C14H23NO.ClH/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12;/h6-9,11,14,16H,5,10H2,1-4H3;1H/t11-,14+;/m0./s1

InChI key

ZELFLGGRLLOERW-YECZQDJWSA-N

Gene Information

human ... OPRM1(4988) , SLC6A2(6530)

General description

Tapentadol represents the first new drug of the centrally-acting analgesic class approved in the US in more than 25 years. This Snap-N-Spike® Reference Solution is suitable for many LC/MS or GC/MS applications, including forensic analysis, pharmaceutical analysis, pain prescription monitoring, and urine drug testing.

Application

  • Extended-Release Formulation for Chronic Pain: Extended-release formulations of Tapentadol hydrochloride are developed to provide sustained pain relief for chronic conditions. This formulation reduces the frequency of dosing and enhances patient compliance, offering consistent pain management (Faria et al., 2017).
  • Pharmaceutical Quality Control and Research: High-purity Tapentadol hydrochloride solutions are essential in pharmaceutical research and quality control. These solutions are used for the calibration of analytical instruments and ensuring the consistency and safety of pharmaceutical products (Fejos et al., 2014).
  • Transdermal Delivery Systems: Innovative research has developed PEGylated ultra-deformable transferosomes for the transdermal delivery of Tapentadol, improving its bioavailability and analgesic activity. This method offers a non-invasive alternative for pain management (Deng et al., 2022).
  • Innovative Pain Management Solutions: Research on new delivery methods, such as intranasal administration using chitosan nanoparticles, aims to enhance the therapeutic potential and patient compliance of Tapentadol hydrochloride solution for pain management (Javia & Thakkar, 2017).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Protocols

LC/MS (TOF) Analysis of Drugs and Their Glucuronide Metabolites in Urine on Titan™ C18 after Solid Phase Extraction (SPE) using Supel™-Select SCX, β-Glucuronidase Enzyme Digestion

-THC solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material

Using UHPLC/MS (TOF) for Detection of Drugs and Metabolites in Urine Following Optimized Enzymatic Hydrolysis Conditions

To optimize hydrolysis using β-glucuronidase, factors such as incubation time, temperature, hydrolysis pH, enzyme source, and enzyme concentration must be evaluated for each glucuronide metabolite to be analyzed.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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