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925136

Sigma-Aldrich

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine

Synonym(s):

2-Sulfonylpyridine, Cysteine-reactive electrophile, SNAr probe

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About This Item

Empirical Formula (Hill Notation):
C8H10N2O3S
CAS Number:
2429964-95-2
Molecular Weight:
214.24
NACRES:
NA.22

reaction suitability

reagent type: chemical modification reagent

Quality Level

100

storage temp.

2-8°C

Application

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine is a sulfoxide-containing fragment for covalent ligand discovery via cysteine labeling as demonstrated by Zamboldo and coworkers. Fragment electrophiles are useful in chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins.

Related useful products may include cysteine fragment KB02 (912131), IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059).

Other Notes

2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Claudio Zambaldo et al.
Journal of the American Chemical Society, 142(19), 8972-8979 (2020-04-18)
The emerging use of covalent ligands as chemical probes and drugs would benefit from an expanded repertoire of cysteine-reactive electrophiles for efficient and diverse targeting of the proteome. Here we use the endogenous electrophile sensor of mammalian cells, the KEAP1-NRF2

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