901297
Polyester bis-MPA dendron 4 NHBoc, 1 azide (core)
generation 2
Synonym(s):
Bis-MPA dendron, PFd-G2-Azide-NH-BOC
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About This Item
Empirical Formula (Hill Notation):
C53H89N7O22
Molecular Weight:
1176.31
UNSPSC Code:
12352125
NACRES:
NA.23
description
4 NHBoc, 1 azide (core)
Quality Level
form
solid
mol wt
generation 2
no. Surface Groups
4
color
white to off-white
functional group
azide (core)
storage temp.
−20°C
General description
- Polymer architecture: Dendron
- End Group Functionality: Boc-protected amine
- Boc : tert-Butyloxycarbonyl
- Bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid.
Application
Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. After Boc deprotection, amine-functionalized dendrons can be readily used in EDC or DCC coupling reactions with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications. Additionally, the azide-core can be readily conjugated using either copper(I)-catalysed alkyne-azide cycloaddition (CuAAC) or strain-promoted alkyne-azide cycloaddition (SPAAC).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been
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