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728632

Sigma-Aldrich

Poly(N-isopropylacrylamide), maleimide terminated

average Mn 5,500

Synonym(s):

P(NIPAM)n-NH-maleimide, Polyacrylamide, functionalized polyNIPAM, functionalized polyacrylamide, polyNIPAM

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About This Item

Linear Formula:
(C6H11NO)n SCH2CH2NH(CO)CH2CH2CH2(C4H2NO2)
UNSPSC Code:
12162002
NACRES:
NA.23

form

solid

mol wt

average Mn 5,500

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Application

PNIPAM-based Smart Surfaces for Cell Sheet Tissue Engineering
Novel polymer for development of thermosensitive coated micro/nano materials including thermoresponsive polymeric drug delivery systems. The maleimide functional group can be used to conjugate a variety of biomolecules such as enzymes and DNA to the polymer chain.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKBN4230V
MKBF1106

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N-Isopropylacrylamide 97%

Sigma-Aldrich

415324

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Sigma-Aldrich

H8502

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Chung, J. E.; Yokoyama, M.; Suzuki, K.; Aoyagi, T.; Sakurai, Y.; Okano, T.
Colloids and Surfaces, B: Biointerfaces, 9, 37-37 (1997)
Safak, M.; Alemdaroglu, F. E.; Li, Y.; Ergen, E.; Hernnann, A.
Advanced Materials, 19, 1499-1499 (2007)
Karina L Heredia et al.
Macromolecules, 42(7), 2360-2367 (2009-01-01)
In this report we describe a straightforward approach to synthesize polymers with end-groups that bind site-specifically to two different proteins. Telechelic biotin, maleimide poly(
Hua Wei et al.
Biomaterials, 28(1), 99-107 (2006-09-09)
A four-arm star block copolymer, comprised of a hydrophobic PMMA arm and an average of three hydrophilic poly(N-isopropylacrylamide) (PNIPAAm) arms were designed and synthesized from the molecular level. The amphiphilic star block copolymer is capable of self-assembling into micelles in
K Fujimoto et al.
Biomacromolecules, 1(4), 515-518 (2001-11-17)
We report a novel drug delivery system for apoptosis induction by a "smart" polymer vehicle possessing thermosensitivity and bioaffinity. The polymer chain was prepared by copolymerization of N-isopropylacrylamide and N-methacryloyloxysuccinimide. Cell-adhesive RGDS peptide was conjugated with the copolymer as a

Articles

Designing temperature and pH sensitive NIPAM based polymers

Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.

Poly(N-isopropylacrylamide)-based Smart Surfaces for Cell Sheet Tissue Engineering

Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.

Stimuli-Responsive Materials as Intelligent Drug Delivery Systems

By altering the physicochemical properties, smart or intelligent drug delivery systems can be designed to deliver therapeutic molecules on-demand. Learn more about the application of stimuli-responsive materials in drug delivery.

Micro- and Nanofabricated Biomaterials for the Study of Cells and Microtissues

Biomaterials science involves the design and fabrication of smart materials for studying, directing, or mimicking biology. For successful integration of biomaterials in biological research, a meaningful understanding of biological systems is required.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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