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Sigma-Aldrich

2-Adamantylamine hydrochloride

99%

Synonym(s):

2-Adamantanamine hydrochloride, 2-Aminoadamantane hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H17N · HCl
CAS Number:
10523-68-9
Molecular Weight:
187.71
Beilstein:
4297901
EC Number:
234-074-2
MDL number:
MFCD00074743
UNSPSC Code:
12352100
PubChem Substance ID:
24849376
NACRES:
NA.22

Assay

99%

form

solid

mp

>300 °C (lit.)

SMILES string

Cl.NC1[C@@H]2C[C@H]3C[C@@H](C2)C[C@@H]1C3

InChI

1S/C10H17N.ClH/c11-10-8-2-6-1-7(4-8)5-9(10)3-6;/h6-10H,1-5,11H2;1H/t6-,7+,8-,9+,10?;

InChI key

WLDWDRZITJEWRJ-ZDAMNCSYSA-N

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General description

The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied.

Application

2-Adamantylamine hydrochloride was used to prepare 2-adamantylamide of 2′-(carboxymethoxime)-olivomycin I.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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C Clark et al.
Immunopharmacology, 21(1), 41-50 (1991-01-01)
The present in vitro investigations on amantadine (AmTd) and its isomer 2-aminoadamantane (2-NH2-Adam), and the corresponding analogs, 1-nitroadamantane (1-NO2-Adam) and 2-nitroadamantane (2-NO2-Adam), were undertaken to gain information about molecular features that might have a dominant role in inhibiting T lymphocyte
Yasuhiko Higashi et al.
Biomedical chromatography : BMC, 20(5), 423-428 (2005-09-15)
Simultaneous HPLC assay of 1-adamantanamine hydrochloride (amantadine) and its four related compounds [2-adamantanamine hydrochloride (2-ADA), 1-adamantanmethylamine (ADAMA), 1-(1-adamantyl)ethylamine hydrochloride (rimantadine) and 3,5-dimethyl-1-adamantanamine hydrochloride (memantine)] in phosphate-buffered saline (pH 7.4) after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) was developed. Phosphate-buffered saline samples
Anna N Tevyashova et al.
The Journal of antibiotics, 62(1), 37-41 (2009-01-10)
A novel way of chemical modification of the antibiotic olivomycin I at the 2'-keto group of the side chain of the aglycone moiety was developed. Reaction of olivomycin I with the carboxymethoxylamine hemihydrochloride gave the key intermediate, 2'-carboxymethoxime-olivomycin I, which
S V Krapivin et al.
Biulleten' eksperimental'noi biologii i meditsiny, 116(11), 515-518 (1993-11-01)
The action of the new stimulant bromantane on spectra power EEG on Fourier of sensorimotor cortex, dorsal hippocamp and lateral hypothalamus of left and right hemispheres of brain of rat in free behavior was investigated. Bromantane leads to decreases in
Anastasiya V Lastovka et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1132, 121813-121813 (2019-11-11)
The methods for quantification of highly potent analgesic agent (2R,4aR,7R,8aR)-4,7-dimethyl-2-(thiophen-2-yl)octahydro-2H-chromen-4-ol in rat whole blood and plasma were developed and validated using dried matrix spots (DMS) or fabric phase sorptive extraction (FPSE) techniques in combination with LC-MS/MS. 2-Adamantylamine hydrochloride was used
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