- Single-cell mass cytometry and transcriptome profiling reveal the impact of graphene on human immune cells.
Single-cell mass cytometry and transcriptome profiling reveal the impact of graphene on human immune cells.
Nature communications (2017-10-25)
Marco Orecchioni, Davide Bedognetti, Leon Newman, Claudia Fuoco, Filomena Spada, Wouter Hendrickx, Francesco M Marincola, Francesco Sgarrella, Artur Filipe Rodrigues, Cécilia Ménard-Moyon, Gianni Cesareni, Kostas Kostarelos, Alberto Bianco, Lucia G Delogu
PMID29061960
ABSTRACT
Understanding the biomolecular interactions between graphene and human immune cells is a prerequisite for its utilization as a diagnostic or therapeutic tool. To characterize the complex interactions between graphene and immune cells, we propose an integrative analytical pipeline encompassing the evaluation of molecular and cellular parameters. Herein, we use single-cell mass cytometry to dissect the effects of graphene oxide (GO) and GO functionalized with amino groups (GONH
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