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Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation.

Proceedings of the National Academy of Sciences of the United States of America (2017-06-28)
Michael V Airola, Prajna Shanbhogue, Achraf A Shamseddine, Kip E Guja, Can E Senkal, Rohan Maini, Nana Bartke, Bill X Wu, Lina M Obeid, Miguel Garcia-Diaz, Yusuf A Hannun
ABSTRACT

Neutral sphingomyelinase 2 (nSMase2, product of the

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Sigma-Aldrich
O-(4-Nitrophenylphosphoryl)choline