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Merck

Hepatic tumors: dynamic MR imaging.

Radiology (1987-04-01)
K Ohtomo, Y Itai, K Yoshikawa, T Kokubo, N Yashiro, M Iio, K Furukawa
ABSTRACT

Thirty-six patients with hepatic tumors (28 hepatocellular carcinomas, seven cavernous hemangiomas, one metastatic tumor) were examined with serial magnetic resonance (MR) imaging, after a bolus intravenous injection of 0.05 mmol/kg gadolinium-diethylenetriaminepentaacetic acid. A typical MR imaging pattern for hemangiomas (present in five of seven cases [71.4%]) was a lesion of diminished signal intensity on precontrast images, peripheral contrast enhancement during the bolus dynamic phase, and complete fill-in of high signal intensity on delayed scan images. Twenty-eight hepatocellular carcinomas showed a variety of contrast enhancement patterns during the dynamic phase. In 21 patients (75%), there was no area of high signal intensity within the tumor on the delayed phase. A peripheral halo with delayed enhancement was noticed in 12 patients (42.8%) Histologic correlation in hepatocellular carcinomas showed that the degree of contrast enhancement corresponded to tumor vascularity and that the peripheral halo corresponded to fibrous capsular structure.

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Sigma-Aldrich
Diethylenetriaminepentaacetic acid gadolinium(III) dihydrogen salt hydrate, 97%