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Merck

Thioredoxin induces Tregs to generate an immunotolerant tumor microenvironment in metastatic melanoma.

Oncoimmunology (2015-09-26)
Xiaogang Wang, Haisheng Dong, Qi Li, Yingxian Li, An Hong
ABSTRACT

Metastatic melanoma is a highly aggressive cancer that is very difficult to treat. Additionally, the antitumor immune reaction of melanoma is still unclear. Here we demonstrate an association between the expression and secretion of the antioxidant protein thioredoxin (TRX) and increasing tumor stage and metastasis in melanoma. To elucidate the role of TRX in melanoma, we assessed the correlation of TRX expression with different disease parameters in melanoma. We also examined the

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Sigma-Aldrich
Perossido di idrogeno, 30 % (w/w) in H2O, contains stabilizer
Sigma-Aldrich
Ethyl alcohol, Pure, 190 proof, ACS spectrophotometric grade, 95.0%
Sigma-Aldrich
Perossido di idrogeno, 34.5-36.5%
Sigma-Aldrich
9,10-Dihydroacridine, AldrichCPR