First total synthesis of the 2,7-naphthyridine alkaloids lophocladine a and B.

First total synthesis of the 2,7-naphthyridine alkaloids lophocladine a and B.

Archiv der Pharmazie (2006-11-17)

Matthias Lotter, Johannes Schilling, Eberhard Reimann, Franz Bracher

ABSTRACT

The one-pot reaction of 4-benzylpyridine-3-carbonitrile with Bredereck's reagent and subsequent treatment with either glacial acetic acid and sulfuric acid or ammonium acetate provided the new bioactive naphthyridine alkaloids lophocladine A and B, respectively.

MATERIALI

N° Catalogo

Marchio

Descrizione del prodotto

384216

Sigma-Aldrich

tert-Butoxy bis(dimethylamino)methane