Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.

Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.

Science (New York, N.Y.) (1966-03-25)

M B Sporn, C W Dingman, H L Phelps, G N Wogan

ABSTRACT

Aflatoxin B(1) binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and carcinogenicity of aflatoxin B(1) may be direct results of the affinity of this agent for DNA.

MATERIALI

N° Catalogo

Marchio

Descrizione del prodotto

34029

Supelco

Aflatoxin B₁ solution, 2 μg/mL in acetonitrile, analytical standard

46323-U

Supelco

Aflatoxin B₁ solution, 3 μg/mL in benzene:acetonitrile (98:2), analytical standard