- First total synthesis of martinellic acid, a naturally occurring bradykinin receptor antagonist.
First total synthesis of martinellic acid, a naturally occurring bradykinin receptor antagonist.
Organic letters (2001-07-07)
D Ma, C Xia, J Jiang, J Zhang
PMID11440576
ABSTRACT
[reaction: see text] The first total synthesis of martinellic acid, a naturally occurring bradykinin receptor antagonist, via a CuI-catalyzed coupling reaction of beta-amino ester 6 with 1,4-diiodobenzene and a guanylation reaction of secondary amine 3 under mild conditions as key steps, is described.
MATERIALI