- Formal total synthesis of (+)-gephyrotoxin.
Formal total synthesis of (+)-gephyrotoxin.
The Journal of organic chemistry (2008-07-22)
Marco Santarem, Corinne Vanucci-Bacqué, Gérard Lhommet
PMID18637692
ABSTRACT
An efficient formal total synthesis of (+)-gephyrotoxin is described. The key step of our strategy relies on the diastereoselective reduction of a chiral pyrrolidine beta-enamino ester obtained by condensation of ( S)-phenylglycinol on a protected 8-hydroxy-3,6-dioxooctanoate.
MATERIALI