Novel three-component route to diastereoselective synthesis of trisubstituted vinylphosphonates using phosphites, acetylenic esters, and aroyl chlorides.

Trisubstituted vinylphosphonates have been prepared via three-component reaction using phosphites, acetylenic esters, and aroyl chlorides in good yields. A variety of phosphites, activated acetylenes, and aroyl chlorides have been successfully employed in these reactions. In addition, three-component synthesis of vinylphosphonate provides exclusive E-olefin stereochemistry.