- Site-selective conversion of azido groups at carbonyl α-positions into oxime groups leading triazide to a triple click conjugation scaffold.
Site-selective conversion of azido groups at carbonyl α-positions into oxime groups leading triazide to a triple click conjugation scaffold.
Chemical communications (Cambridge, England) (2018-12-21)
Taiki Yokoi, Tomomi Ueda, Hiroki Tanimoto, Tsumoru Morimoto, Kiyomi Kakiuchi
PMID30569047
ABSTRACT
This paper reports the selective conversion of alkyl azido groups at the carbonyl α-position into oximes through β-elimination of dinitrogen, followed by transoximation. With this method and diazo conversion, a triazido molecule was transformed into a triple click conjugation scaffold allowing one-pot four-component coupling.
MATERIALI
N° Catalogo
Marchio
Descrizione del prodotto