SML2392

DREADD Agonist 21 dihydrochloride

≥98% (HPLC), powder, DREADD agonist

• Sinonimo/i: 11-(1-piperazinyl)-5H-Dibenzo[b,e][1,4]diazepine dihydrochloride, 11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine; 11-Piperazinyldibenzo[b,e][1,4]diazepine dihydrochloride, Compound 21 dihydrochloride
• Formula empirica (notazione di Hill): C₁₇H₁₈N₄ · 2HCl
• Numero CAS: 56296-18-5
• Peso molecolare: 351.27
• Numero MDL: MFCD25121806
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Nome del prodotto: DREADD Agonist 21 dihydrochloride, ≥98% (HPLC)
• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: yellow to brown
• Solubilità: H₂O: 2 mg/mL, clear
• Temperatura di conservazione: −20°C
• Stringa SMILE: C1(C=CC=C2)=C2C(N3CCNCC3)=NC(C=CC=C4)=C4N1
• InChI: 1S/C17H18N4/c1-2-6-14-13(5-1)17(21-11-9-18-10-12-21)20-16-8-4-3-7-15(16)19-14/h1-8,18-19H,9-12H2; JCBYXNSOLUVGTF-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

Compound 21 is a potent designer drug with full agonist activity toward human hM3Dq (EC50 = 1.7 nM by cell-based Ca2+ mobilization assay), a human M3 muscarinic receptor (M3R)-based Gq (M3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs), displaying little activity toward muscarinic acetylcholine receptor M3 (30% M3 activation at 10 μM) and reduced affinity toward H1, 5HT2A, 5HT2C, α1A receptor (fold selectivity = 3.5, 40, 100, 165, respectively). Note: the DREADD hM3Dq exhibits M3 biological activity, but is insensitive to the endogenous ligand acetylcholine (ACh).

Potent designer drug with selective agonist activity for human M3Dq (hM3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs).

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable