SML0177

AUDA

≥98% (HPLC)

• Sinonimo/i: 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid
• Formula empirica (notazione di Hill): C₂₃H₄₀N₂O₃
• Numero CAS: 479413-70-2
• Peso molecolare: 392.58
• Numero MDL: MFCD12912267
• Codice UNSPSC: 12352200
• ID PubChem: 329825206
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white to beige
• Solubilità: DMSO: ≥10 mg/mL at warmed to 60 °C
• Temperatura di conservazione: −20°C
• Stringa SMILE: OC(=O)CCCCCCCCCCCNC(=O)NC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2
• InChI: 1S/C23H40N2O3/c26-21(27)10-8-6-4-2-1-3-5-7-9-11-24-22(28)25-23-15-18-12-19(16-23)14-20(13-18)17-23/h18-20H,1-17H2,(H,26,27)(H2,24,25,28)/t18-,19+,20-,23-; XLGSEOAVLVTJDH-UKBVAGSOSA-N

Descrizione

Applicazioni

AUDA has been used in the inhibition of epoxide hydrolase in human macrophages and in inhibition of tumor necrosis factor α (TNF-α)- induced phosphorylation in human aortic smooth muscle cells.

AUDA may be used in soluble epoxide hydrolase-mediated cell signaling studies.

Azioni biochim/fisiol

Inhibition of soluble epoxide hydrolase by AUDA inhibits the metabolism of epoxyeicosatrienoic acids (EETs) and protects end-organs against the damaging effects of salt-sensitive hypertension. AUDA also renders protection against myocardial ischemia-reperfusion injury and cerebral ischemia.

AUDA is a potent inhibitor of soluble epoxide hydrolase

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable