P0035

Penciclovir

• Sinonimo/i: 2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one, BRL-39123
• Formula empirica (notazione di Hill): C₁₀H₁₅N₅O₃
• Numero CAS: 39809-25-1
• Peso molecolare: 253.26
• Numero MDL: MFCD15142866
• Codice UNSPSC: 51102829
• ID PubChem: 329819986
• NACRES: NA.76

Proprietà

• Forma fisica: powder
• Livello qualitativo: 100
• Solubilità: 0.02 M potassium phosphate: soluble 2 mg/mL
• Spettro attività antibiotica: viruses
• Modalità d’azione: DNA synthesis | interferes; enzyme | inhibits
• Stringa SMILE: NC1=NC(=O)c2ncn(CCC(CO)CO)c2N1
• InChI: 1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18); JNTOCHDNEULJHD-UHFFFAOYSA-N

Descrizione

Applicazioni

Penciclovir is a selective antiherpesvirus agent, particularly against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV).

Azioni biochim/fisiol

Penciclovir is converted to its active form, penciclovir triphosphate, by cellular kinases. It inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. It inhibits DNA synthesis of virus-infected cells. Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). It does not inhibit DNA synthesis in non-infected cells. Mode of resistance is via qualitative changes in viral thymidine kinase or DNA polymerase.

Altre note

Keep container tightly closed in a dry and well-ventilated place.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable