250233

Cytochalasin B

from Helminthosporium dematioideum, ≥98% (HPLC), solid, cell-permeable fungal toxin, Calbiochem^®

• Sinonimo/i: Cytochalasin B, Helminthosporium dematioideum
• Formula empirica (notazione di Hill): C₂₉H₃₇NO₅
• Numero CAS: 14930-96-2
• Peso molecolare: 479.61
• Numero MDL: MFCD00077704
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• product name: Cytochalasin B, Helminthosporium dematioideum, Cell-permeable fungal toxin.
• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: white
• Solubilità: methanol: 20 mg/mL; DMSO: 50 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: 1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1; GBOGMAARMMDZGR-TYHYBEHESA-N

Descrizione

Descrizione generale

Cell-permeable fungal toxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inhibits cell movement and induces nuclear extrusion. Shortens actin filaments by blocking monomer addition at the fast growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.

Cell-permeable fungal toxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inhibits cell movement and induces nuclear extrusion. Shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
Blocking the formation of contractile microfilaments

Product does not compete with ATP.

Reversible: no

Avvertenza

Poor quality DMSO will cause degradation of the product, so high quality DMSO is recommended.

Attenzione

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

Ricostituzione

Following reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.

Altre note

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Tanaka, Y., et al. 1994. Exp. Cell Res. 213, 242.
Theodoropoulos, P.A., et al. 1994. Biochem. Pharmacol. 47, 1875.
Benya, P.D., and Padilla, S.R. 1993. Exp. Cell Res. 204, 268.
Cairns, M.T., et al. 1991. J. Biol. Chem.266, 8176.
Nowak, D. 1990. Biomed. Biochim. Acta49, 353.
Wang, F., et al. 1990. Biochem. Biophys. Res. Commun.171, 543.
Edwards, S.W., and Lloyd, D. 1988. FEBS Lett.227, 39.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H300 + H310 + H330,H361
• Consigli di prudenza: P201 - P202 - P260 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Classi di pericolo: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3