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Merck

NOTCH3

notch 3

Sinonimi:
CADASIL, CASIL, IMF2
Specie:
ID UniProtKB:
ID gene:
  • Human(4854) Summary: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
  • Mouse(18131) notch 3
  • Rat(56761) notch 3
  • Zebrafish(58066) notch homolog 3
  • dog(610439) notch 3
  • domestic cat(101088469) notch 3
  • cow(789485) notch 3
  • sheep(101123554) notch 3
  • domestic guinea pig(100716867) notch 3
  • naked mole-rat(101722220) notch 3

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ELISA

N° Catalogo
Descrizione
Specie
Human Notch-3 ELISA, for serum, plasma and cell culture supernatants,
Specie
human

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-NOTCH 3/N3ECD Antibody, clone 1E4, clone 1E4, 1 mg/mL, from mouse,
Reattività con
human
Applicazione
electron microscopy
immunocytochemistry

western blot
Monoclonal Anti-NOTCH3 antibody produced in mouse, clone 2E2, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
immunofluorescence

western blot
Anti-NOTCH3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
Anti-Notch 3 Antibody, clone 1G17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
human, mouse, rat
Applicazione
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-NOTCH3 (C-terminal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
DAPT, ≥98% (HPLC), solid,
Specie
mouse, human, rat
L-685,458, >96% (HPLC), solid,
Specie
mouse, human, rat

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting mouse Notch3,
Specie
mouse
MISSION® esiRNA, targeting human NOTCH3,
Specie
human