MDM4
Mdm4 p53 binding protein homolog (mouse)
Sinonimi:
HDMX, MDMX, MRP1
Specie:
Human MDM4 (4194), Mouse Mdm4 (17248), Rat Mdm4 (304798), sheep MDM4 (101112914), naked mole-rat Mdm4 (101720853), Domestic Rabbit MDM4 (100351683), domestic guinea pig Mdm4 (100719525), Zebrafish mdm4 (334932), cow MDM4 (514225), Horse MDM4 (100050113) ...Più
ID UniProtKB:
ID gene:
- Human(4194) Summary: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
- Mouse(17248) transformed mouse 3T3 cell double minute 4
- Rat(304798) Mdm4 p53 binding protein homolog (mouse)
- sheep(101112914) Mdm4 p53 binding protein homolog (mouse)
- naked mole-rat(101720853) Mdm4 p53 binding protein homolog (mouse)
- Domestic Rabbit(100351683) Mdm4 p53 binding protein homolog (mouse)
- domestic guinea pig(100719525) Mdm4 p53 binding protein homolog (mouse)
- Zebrafish(334932) transformed 3T3 cell double minute 4 homolog (mouse)
- cow(514225) Mdm4 p53 binding protein homolog (mouse)
- Horse(100050113) Mdm4 p53 binding protein homolog (mouse)
- domestic cat(101082460) Mdm4 p53 binding protein homolog (mouse)
- dog(478939) Mdm4 p53 binding protein homolog (mouse)
- chicken(419823) Mdm4 p53 binding protein homolog (mouse)
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Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anticorpo anti-Mdmx, clone 8C6, clone 8C6, from mouse,
Reattività con
human
Applicazione
ChIP
flow cytometry
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-MDM4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reattività con
human
Applicazione
immunofluorescence
western blot
western blot
Anti-MDM4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
Anti-phospho-MDM4 (pSer367) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-MDM4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
immunofluorescence
western blot
western blot