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Merck

KLRK1

killer cell lectin-like receptor subfamily K, member 1

Sinonimi:
CD314, D12S2489E, KLR, NKG2-D, NKG2D
Specie:
Human KLRK1 (22914), Mouse Klrk1 (27007), Rat Klrk1 (24934), cow KLRK1 (404058), dog KLRK1 (611355), domestic cat KLRK1 (101086984), domestic guinea pig Klrk1 (100723644)
ID UniProtKB:
P26718, A8K7K5, A8K7P4, Q9NR41
ID gene:
  • Human(22914) Summary: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]
  • Mouse(27007) killer cell lectin-like receptor subfamily K, member 1
  • Rat(24934) killer cell lectin-like receptor subfamily K, member 1
  • cow(404058) killer cell lectin-like receptor subfamily K, member 1
  • dog(611355) killer cell lectin-like receptor subfamily K, member 1
  • domestic cat(101086984) killer cell lectin-like receptor subfamily K, member 1
  • domestic guinea pig(100723644) killer cell lectin-like receptor subfamily K, member 1

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Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
MABF1032
Anti-NKG2D (CD314) Antibody, clone 1D11, clone 1D11, from mouse,
Reattività con
human
Applicazione
flow cytometry
immunohistochemistry
immunoprecipitation (IP)
SAB1304697
ANTI-NKG2D (N-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reattività con
human
Applicazione
western blot
MABF3094
Anti-BAFF/CD257 Antibody, clone 5A8, ,
Reattività con
mouse
Applicazione
ELISA
activity assay
western blot
SAB4301852
Anti-KLRK1, affinity isolated antibody,
Reattività con
human
Applicazione
immunohistochemistry

esiRNA

N° Catalogo
Descrizione
Specie
EHU128171
MISSION® esiRNA, targeting human KLRC1,
Specie
human
EHU225531
MISSION® esiRNA, targeting human KLRC4-KLRK1,
Specie
human